Secreted Factors from Umbilical Cord-Mesenchymal Stem Cells Affect CD86 Expression on B Lymphocytes and Increase CCL5 Chemokine Secretion by Healthy Donors' PBMC

A growing number of autoimmune diseases, allergies, and atopic conditions in recent years are calling for the development innovative therapies, such as those using stem cells with immunoregulatory activity. Because few often conflicting results scientific literature, it is still uncertain whether mesenchymal (MSC) could be a useful therapeutic strategy targeting B lymphocytes helpful treating allergy patients or variety viral infections. In connection aforementioned, our team investigated influence umbilical cord MSC-secreted factors on healthy donors' B-cell CD86 expression CCL5 secretion by peripheral blood mononuclear (PBMC) vitro. When PBMC were cultivated conditioned medium derived from MSC, density membrane statistically decreased, but percentage expressing this co-stimulatory molecule was slightly significantly increased. We also found increased chemokine under MSC secretome.